Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

TPSAB1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA525355

Catalog No. PIPA525355


Add to cart

Description

Description

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3 ft. UTR and contain tandem repeat sequences at the 5 ft. flank and 3 ft. UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
Specifications

Specifications

TPSAB1
Polyclonal
Unconjugated
TPSAB1
Liquid
TPSAB1
KLH conjugated synthetic peptide between 61-87 amino acids from the central region of human TPSAB1
Protein A, Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Flow Cytometry, Western Blot
0.5 mg/mL
PBS with 0.09% sodium azide
Q15661
TPS1, TPS2, TPSB1, mast cell alpha II tryptase, mast cell beta I tryptase, tryptase I, tryptase alpha II, tryptase alpha-1, tryptase alpha/beta-1, tryptase beta 1, tryptase beta I, tryptase beta-1, tryptase-1, tryptase-I, tryptase-III
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
7177
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit