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TRAF1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527689

Catalog No. PIPA527689


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Description

Description

PA5-27689 targets TRAF1 in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-27689 immunogen is recombit fragment corresponding to a region within amino acids 1 and 228 of Human TRAF1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors.
Specifications

Specifications

TRAF1
Polyclonal
Unconjugated
TRAF1
Liquid
TRAF1
Recombit fragment corresponding to a region within amino acids 1 and 228 of Human TRAF1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
0.87 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Q13077
EBI6, MGC:10353, Epstein-Bar virus-induced protein 6
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
7185
Documents
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