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TRAF7 Rabbit anti-Equine, Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141285

Catalog No. 01-675-626


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Description

Description

Suggested positive control: antigen standard for TRAF7 (transient overexpression lysate).

TRAFs are signal transducers for members of TNFR superfamily. These are critically involved in activation of MAP3K family members involved in NF-kappaB and JNK activation and apoptosis. TRAF7, a novel 670 A.A protein, is a human homolog of mouse Traf7 and consists of an N-terminal RING finger domain, central TRAF domain, a coiled-coil motif and 7 WD40 repeats at the C-terminus. It has E3-ubiquitin ligase activity for self-ubiquitination. TRAF7 specifically interacts with MEKK3 and mediates MEKK3-induced AP1 and CHOP activation and induces apoptosis through Caspase-independent pathways.It is a multifunctional protein involved in sumoylation and negative regulation of c-Myb, thereby regulating proliferation and differentiation of hematopoietic cells.
Specifications

Specifications

TRAF7
Polyclonal
Unconjugated
TRAF7
Liquid
TRAF7
Synthetic peptide corresponding to residues 334-356 of human TRAF7.
Protein G
RUO
Antibody
Polyclonal
Equine, Human, Mouse, Rat
Immunoprecipitation, Western Blot
1.0 mg/mL
PBS with 0.05% sodium azide
Q6Q0C0, Q922B6
DKFZp586I021, MGC7807, RFWD1, RNF119
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100065698, 224619, 360491, 84231
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