TRAF7 Rabbit anti-Equine, Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA141285
Suggested positive control: antigen standard for TRAF7 (transient overexpression lysate).TRAFs are signal transducers for members of TNFR superfamily. These are critically involved in activation of MAP3K family members involved in NF-kappaB and JNK activation and apoptosis. TRAF7, a novel 670 A.A protein, is a human homolog of mouse Traf7 and consists of an N-terminal RING finger domain, central TRAF domain, a coiled-coil motif and 7 WD40 repeats at the C-terminus. It has E3-ubiquitin ligase activity for self-ubiquitination. TRAF7 specifically interacts with MEKK3 and mediates MEKK3-induced AP1 and CHOP activation and induces apoptosis through Caspase-independent pathways.It is a multifunctional protein involved in sumoylation and negative regulation of c-Myb, thereby regulating proliferation and differentiation of hematopoietic cells.
|Synthetic peptide corresponding to residues 334-356 of human TRAF7.|
|Equine, Human, Mouse, Rat|
|Immunoprecipitation, Western Blot|
|PBS with 0.05% sodium azide|
|DKFZp586I021, MGC7807, RFWD1, RNF119|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|100065698, 224619, 360491, 84231|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok