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TRAIL Mouse anti-Human, Clone: 124723, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523771

Catalog No. PIMA523771


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Description

Description

Reconstitute at 0.5 mg/mL in sterile PBS.

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel member in the TNF family was recently identified and designated TRAIL (for TNF-related apoptosis-inducing ligand) and Apo-2L (for Apo-2 ligand) (6,7). TRAIL is a type II membrane protein and expressed in a variety of human tissues. Two novel death domain containing receptors DR4 and DR5 have been identified as the receptor for TRAIL3-6. Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells.
Specifications

Specifications

TRAIL
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P50591
Apo2L, Apo-2 Ligand, TNF-Related Apoptosis-Inducing Ligand, Tumor necrosis factor ligand, superfamily member 10, TRAIL protein, CD253 antigen, TNFSF10
Mouse
IgG1
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
8743
ELISA
124723
Unconjugated
TNFSF10
Lyophilized
TNFSF10
E. coli-derived recombit human TRAIL Val114-Gly281
Protein A/G
RUO
Antibody
Monoclonal
Human
Documents
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