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TRAIL Rat anti-Mouse, Clone: 170533, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA523782

Catalog No. PIMA523782


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Description

Description

This antibody does not cross-react with Recombinant human (rh) APRIL, rhBAFF, Recombinant mouse (rm) BAFF, rhEDA-A2, rmEDA, rhFas Ligand, rmFas Ligand, rhGITR Ligand, rhLIGHT, rhOX40 Ligand, cotton rat TNF-alpha, rhTNF-alpha, rmTNF-alpha, Recombinant porcine TNF-alpha, Recombinant rat TNF-alpha, Recombinant rhesus macaque TNF-alpha, rhTRANCE, rhTWEAK, rhVEGI, or rhTRAIL. Reconstitute at 0.5 mg/mL in sterile PBS.

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel member in the TNF family was recently identified and designated TRAIL (for TNF-related apoptosis-inducing ligand) and Apo-2L (for Apo-2 ligand) (6,7). TRAIL is a type II membrane protein and expressed in a variety of human tissues. Two novel death domain containing receptors DR4 and DR5 have been identified as the receptor for TRAIL3-6. Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells.
Specifications

Specifications

TRAIL
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P50592
Apo2L, Apo-2 Ligand, TNF-Related Apoptosis-Inducing Ligand, Tumor necrosis factor ligand, superfamily member 10, TRAIL protein, CD253 antigen, TNFSF10
Rat
IgG2a
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
22035
ELISA, Western Blot
170533
Unconjugated
Tnfsf10
Lyophilized
TNFSF10
E. coli-derived recombit mouse TRAIL/TNFSF10 Pro118-Asn291
Protein A/G
RUO
Antibody
Monoclonal
Mouse
Documents
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