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TRAIL Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA14171

Catalog No. PA14171


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Description

Description

PA1-4171 detects TRAIL in human samples. PA1-4171 has been successfully used in Western blot procedures. The PA1-4171 immunogen is a synthetic peptide corresponding to the N-terminal residues S(133) N T L S S P N S K N E(144) of human TRAIL.

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including tumor necrosis factor (TNF) and Fas ligand in the TNF family through their death domain containing receptors, TNF receptor 1 (TNFR1) and Fas. Another member in the TNF family has been identified and designated TRAIL (for TNF-related apoptosis inducing ligand) and Apo-2L (for Apo-2 ligand). Receptors for TRAIL include two death domain containing receptors, death receptor 4 (DR4) and DR5, as well as two decoy receptors, DcR1 and DcR2, lacking the intracellular signaling death domain. TRAIL is a type II membrane protein and expressed in a variety of human tissues. Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells.
Specifications

Specifications

TRAIL
Polyclonal
Unconjugated
TNFSF10
Liquid
TNFSF10
Synthetic peptide corresponding to the N-terminal residues S(133) N T L S S P N S K N E(144) of human TRAIL.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P50591
Apo2L, Apo-2 Ligand, TNF-Related Apoptosis-Inducing Ligand, Tumor necrosis factor ligand, superfamily member 10, TRAIL protein, CD253 antigen, TNFSF10
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
8743
Documents
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