DR4 Mouse anti-Human, Clone: 32A1380, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA141076
Suggested positive control: Daudi.Cells undergo programmed cell death (Apoptosis) in response to various stimuli. Apoptosis is essential for morphogenesis, tissue homeostasis, and host defense (1) Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4) (2). The ligand for this novel death receptor has been identified and termed TRAIL (3,4), which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1) (5). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kB activation in many tissues and cells.
|PBS with 0.05% sodium azide|
|APO2, CD261, DR4, MGC9365, TRAILR-1, TRAILR1|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot|
|Synthetic peptide corresponding to residues 2-21 of human DR4 mature protein.|
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