Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

DR4 Mouse anti-Human, Mouse, Rat, Clone: 32A242, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA141049

Catalog No. 01-676-455


Add to cart

Description

Description

Suggested positive control: Hela whole cell extract, HeLa cell lysate.

Cells undergo programmed cell death (Apoptosis) in response to various stimuli. Apoptosis is essential for morphogenesis, tissue homeostasis, and host defense (5). Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4) (4). The ligand for this novel death receptor has been identified and termed TRAIL (2,3), which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1) (1). DR4 is expressed in most human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kB activation in many tissues and cells.
Specifications

Specifications

DR4
Monoclonal
1.0 mg/mL
PBS with 0.05% sodium azide
O00220
APO2, CD261, DR4, MGC9365, TRAILR-1, TRAILR1
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
8797
Immunocytochemistry, Immunofluorescence, Western Blot
32A242
Unconjugated
TNFRSF10A
Liquid
TNFRSF10A
Synthetic peptide corresponding to residues 2-21 of mature human DR4.
Protein G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit