DR4 Mouse anti-Human, Clone: DR-4-02, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119025
Endotoxin level is less than 0.01 EU/ug of the protein, as determined by the LAL test.TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).
|PBS with no preservative; pH 7.4|
|APO2, CD261, DR4, MGC9365, TRAILR-1, TRAILR1|
|4° C, do not freeze|
|Flow Cytometry, Functional Assay, Immunocytochemistry, Immunoprecipitation|
|Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1.|
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