Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Tramadol Sheep anti-Chemical, Polyclonal, Invitrogen™

Sheep Polyclonal Antibody

Manufacturer:  Invitrogen PA175471

Catalog No. PIPA175471


Add to cart

Description

Description

PA1-75471 specifically detects Tramadol. PA1-75471 has been successfully used in ELISA applications. The PA1-75471 immunogen is Tramadol(N)-BTG.

Tramadol is only found in individuals that have used or taken this drug. It is a narcotic analgesic proposed for moderate to severe pain. It may be habituating. [PubChem] Tramadol and its O-desmethyl metabolite (M1) are selective, weak OP3-receptor agonists. Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. The analgesic properties of Tramadol can be attributed to norepinephrine and serotonin reuptake blockade in the CNS, which inhibits pain transmission in the spinal cord. The (+) etiomer has higher affinity for the OP3 receptor and preferentially inhibits serotonin uptake and enhances serotonin release. The (-) etiomer preferentially inhibits norepinephrine reuptake by stimulating alpha(2)-adrenergic receptors. [National Center for Biotechnology Information. PubChem Compound Database; CID=33741]
Specifications

Specifications

Tramadol
Polyclonal
PBS with 0.09% sodium azide
Ultram; Ralivia; Tramal; C16H25NO2
Tramadol(N)-BTG
Purified
RUO
Antibody
Polyclonal
ELISA
Unconjugated
Liquid
Sheep
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
Chemical
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit