Transferrin Receptor Mouse anti-Human, Clone: 3B82A1, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA140198
MA1-40198 detects Transferrin receptor 1 from human samples. MA1-40198 has been successfully used in flow cytometry, ELISA, immunohistochemistry (frozen), immunoprecipitation, and Western blot applications. The MA1-40198 immunogen is human Transferrin receptor 1.Human transferrin receptor 1 (TfR1), also designated CD71, is a homodimeric type II membrane glycoprotein of 90-95 kDa. This receptor binds two molecules of the serum iron-transport protein transferrin (Tf) and is internalised into endosomes that are acidified, resulting in the release of iron from Tf. TfR1 is not expressed on resting leukocytes but is upregulated on all proliferating cells upon activation, reflecting the iron dependence of proliferation. In tissues TfR1 is expressed on most dividing cells and on brain capillary endothelium. Expression of TfR1 is down regulated as a result of iron overload. TfR1 shares 45% identity with TfR2. Cellular uptake of iron occurs via receptor mediated endocytosis of ligand occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Useful in studies of dividing haematopoietic and tumour cell populations, and metabolic activity.
|PBS with 0.1% BSA and 0.02% sodium azide|
|CD71, T9, TFR, TFR1, TR, TRFR, p90, transferrin receptor protein 1|
|ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot|
|Human Transferrin receptor 1.|
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