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Transferrin Receptor/CD71 Monoclonal Antibody, Clone: H68.4, Invitrogen™ Non-distribution product as customer accommodation.

Transferrin Receptor/CD71 Antibody (H68.4), 13-6890, from Invitrogen™. Species Reactivity: Chicken, Hamster, Human, Mouse, Rat; Applications: ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunomicroscopy, Immunoprecipitation, Western Blot

Manufacturer:  Invitrogen 136890

Catalog No. 13-689-0


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Specifications

Description

Transferrin Receptor/CD71 Antibody (H68.4), 13-6890, from Invitrogen™. Species Reactivity: Chicken, Hamster, Human, Mouse, Rat; Applications: ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunomicroscopy, Immunoprecipitation, Western Blot

CD71 (transferrin receptor) is a type II transmembrane glycoprotein expressed as homodimer in erythroid blood cell line and in activated leukocytes. Upon binding of holotransferrin (complex of transferrin and iron ions), CD71 is internalized by clathrin-mediated endocytosis. Acidification of endosomes by vesicular membrane proton pumps leads to dissociation of iron ions, whereas transferrin (apotransferrin) remains associated with CD71 and recycles to the cell surface, where it is released upon exposure to normal pH. CD71 is also involved in uptake of non-transferrin bound iron.
Host Species: Mouse
Cross Reactivity: Chicken, Hamster, Human, Mouse, Rat
Isotype: IgG1
Clone: H68.4
Immunogen: Recombinant human transferrin receptor.
Formulation: 500µg purified antibody in PBS and 0.1% sodium azide; pH 7.4
Synonyms: CD71, T9, TFR, TFR1, TR, TRFR, p90, transferrin receptor protein 1
Uniprot Accession: P02786, Q62351, Q90997, Q99376
Entrez GeneID: 22042, 396191, 64678, 7037
Gene Symbol: TFRC
This product detects Transferrin Receptor/CD71 in Chicken, Hamster, Human, Mouse and Rat samples. This product has been successfully used in ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunomicroscopy, Immunoprecipitation and Western Blot procedures. The immunogen is Recombinant human transferrin receptor..
References:
Test: Flow, Species: Hm, Reference: Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef. (2011) PLoS ONE, Vol: 6, 5, e20033, Breuer S,Schievink SI,Schulte A,Blankenfeldt W,Fackler OT,Geyer M; Pubmed ID: 21625496
Description & Specifications

Specifications

Transferrin Receptor/CD71
Unlabeled
P02786, Q62351, Q90997, Q99376
Murine
IgG1
Store at -20°C
Monoclonal
Chicken,Hamster,Human,Murine,Rat
H68.4
500μg of Affinity chromatography antibody in PBS with 0.1% sodium azide; pH 7.4.
Affinity Purified
Recombinant human transferrin receptor.
Affinity chromatography
Primary
22042, 396191, 64678, 7037
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