TGM2 Mouse anti-Human, Clone: 14G2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen LFMA0094

Catalog No. AML0094

Description

A suggested positive control for this product is U87-MG cells.

Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer′s disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.

Specifications

• Antigen: TGM2
• Classification: Monoclonal
• Concentration: 2 mg/mL
• Gene: TGM2
• Gene Alias: C polypeptide, G alpha h, G protein alpha subunit Gh class,
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 7052
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
• Clone: 14G2
• Conjugate: Unconjugated
• Gene Accession No.: P21980
• Gene Symbols: TGM2
• Immunogen: Purified, recombit, human transglutaminase 2 protein expressed in E. coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1