TGM2 Mouse anti-Human, Clone: 14G2, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen LFMA0094
A suggested positive control for this product is U87-MG cells.Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer′s disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.
|C polypeptide, G alpha h, G protein alpha subunit Gh class,|
|-20° C, Avoid Freeze/Thaw Cycles|
|ELISA, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot|
|Purified, recombit, human transglutaminase 2 protein expressed in E. coli.|
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