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TSN Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA521150

Catalog No. PIPA521150


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Description

Description

A suggested positive control is rat lung tissue lysate. PA5-21150 can be used with blocking peptide PEP-1264.

Translin is a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. Recent evidence suggests that in combination with a binding partner Trax, Translin binds RNA and mediates trafficking in neurons.
Specifications

Specifications

TSN
Polyclonal
Unconjugated
TSN
Liquid
TSN
A 20 amino acid peptide near the carboxy terminus of human Translin.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q15631, Q62348
BCLF-1, RCHF1, REHF-1, TBRBP, TRSLN; recombination hotspot associated factor; recombination hotspot-binding protein
Rabbit
IgG
100 μg
4° C
Primary
22099, 60381, 7247
Documents
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