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TREX2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520666

Catalog No. PIPA520666


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Description

Description

A suggested positive control is rat liver tissue lysate. PA5-20666 can be used with blocking peptide PEP-0786.

TREX2 is one of two major human 3 ft. to 5 ft. exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2-single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double stranded DNA and feed the substrate DNA strand into the TREX2 active site. At least two isoforms of TREX2 are known to exist.
Specifications

Specifications

TREX2
Polyclonal
Unconjugated
TREX2
Liquid
TREX2
A 15 amino acid peptide near the carboxy terminus of human TREX2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9BQ50, Q9R1A9
3′-5′ exonuclease TREX2 long form
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
11219, 24102, 309275
Documents
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