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TRF2 Mouse, Unlabeled, Clone: 36, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611200

Catalog No. BDB611200


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Description

Description

Telomeres, the physical ends of eukaryotic chromosomes, consist of tracts of TTAGGG repeats that end in 3 ft. single strand protrusions called G-strand overhangs. TRF2 (TTAGGG Repeat binding Factor-2) and TRF1 are two proteins that bind the TTAGGG repeats of mammalian telomeres. Both proteins are ubiquitously expressed and exhibit a similar overall structure with a C-terminal DNA binding motif related to the protooncogene Myb and an N-terminal putative dimerization domain. While TRF1 is a negative regulator of telomere length maintenance, TRF2 is involved in the protection of chromosome ends from end-to-end fusion. Telomere integrity is maintained through the formation of “t loops” which are made by the insertion of the G-strand overhang into the duplex repeat region. This structural alteration is mediated by TRF2 and is the primary mechanism for the sequestration and protection of telomeres from DNA damage responses. Cells that lack functional TRF2 undergo loss of G-strand overhangs, innapropriate DNA repair resulting in end-to-end chromosome fusion, cell cycle arrest and apoptosis. Thus, TRF2 is a unique and vital component for the maintenance of chromosome structure and function.

Host Species: Mouse
Clone: 36
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human TRF2 aa. 316-427
Formula Weight [Chemical]: 66kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

TRF2
36
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
TTAGGG Repeat binding Factor-2
Affinity Purified
Human TRF2 aa. 316-427
50μg
Cell Biology
Primary
Canine, Human
Documents
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