Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

TRF2 Mouse anti-Human, Mouse, Rat, Clone: 4A794.15, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA141001

Catalog No. 01-676-430


Add to cart

Description

Description

The TRF2 antibody is referred to as both clone 4A794.15 and 4A794 in the published literature. This antibody recognizes full-length TRF2 as well as TRF2 forms lacking both the N-terminal basic domain (B) and the telobox Myb-like C-terminal DNA-binding domain (M). TRF2 forms missing the B and M domains are often referred to as mutant TRF2.Although the exact epitope recognized by the TRF2 antibody has not been mapped, the scientific literature indicates it is in the D or L domain, but not in the B or M domain. Suggested positive control: HL-60, antigen standard for TERF2 (transient overexpression lysate).

TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length (1). TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes (1). TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini (2). The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells (2). Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types (3). 1. Broccoli, D., et al. Nature Genetics 17:231-239 (1997). 2. Van Steensel B., et al. Cell 92:401-413 (1998). 3. Karlseder, J., et al. Science 283: 1321-1325 (1999).
Specifications

Specifications

TRF2
Monoclonal
1 mg/mL
PBS with 0.05% sodium azide
Q15554, O35144
TRBF2, TRF2
Mouse
IgG1, kappa
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
21750, 361403, 7014
ChIP assay, ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen)
4A794.15
Unconjugated
TERF2
Liquid
TERF2
Full-length TRF2 protein.
Protein G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit