Tri-Methyl-Histone H3 (Lys4) Rabbit anti-Human, Many, Mouse, Plant, Zebrafish, Polyclonal, Invitrogen™ 

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen 491005

Catalog No. 49-100-5

Description

Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Post tranlationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.

Specifications

• Antigen: Tri-Methyl-Histone H3 (Lys4)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HIST1H3A
• Format: Liquid
• Gene Symbols: HIST1H3A
• Immunogen: Raised against the region of the histone H3 containing the trimethylated lysine 4 (or [K4me3]), using a KLH-conjugated synthetic peptide.
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Polyclonal
• Target Species: Human, Many, Mouse, Plant, Zebrafish

• Applications: ChIP assay, ChIP-sequencing, ELISA, Immunocytochemistry, Immunofluorescence, Peptide Array, Western Blot
• Concentration: 1.4 mg/mL
• Formulation: PBS with 0.05% Proclin 300, 0.05% sodium azide
• Gene Accession No.: P68431, P68433
• Gene Alias: H3K4me3, Histone H3, Histone 1, H3a, Histone H3.1, histone H3/a, HIST1H3A
• Host Species: Rabbit
• Isotype: IgG
• Quantity: 50 μg
• Storage Requirements: -20° C, Avoid Freeze/Thaw Cycles
• Primary or Secondary: Primary
• Gene ID (Entrez): 360198, 8350