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RNF216 Rabbit anti-Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112838

Catalog No. 01-675-829


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Description

Description

Activation of NF-κB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88. Several regulatory mechanisms exist to control TLR signal transduction, including the inhibition of TLR expression and signaling by molecules such as ST2 and SIGIRR. Another mechanism is by the ubi-quitinization of selected TLRs by TRIAD3A, an E3 ubiquitin-protein ligase. TRIAD3A is a RING finger protein that can bind to TLR4 and TLR9, and to a lesser extent TLR3 and TLR5, catalyzing the ubiquitization of these molecules. Overexpression of TRIAD3A promoted the nearly complete degradation of TLR4 and TLR9; this reduction was reflected in the decreased signal-specific activation by ligands specific for these TLRs. Conversely, depletion of TRIAD3A resulted in enhanced TLR activation.

A suggested positive control for this product is testis or peripheral blood leukocytes.
Specifications

Specifications

RNF216
Polyclonal
PBS with 0.02% sodium azide
P58283
2810055G22Rik, AI647468, AU019462, C86502, F830018F18Rik, TRIAD3, UIP83, Ubce7ip1
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
108086
Western Blot
Unconjugated
Rnf216
Liquid
RNF216
Synthetic peptide corresponding to 15 residues near the N-terminus of mouse TRIAD3A.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Mouse
Documents
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