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TRIB3 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141018

Catalog No. 01-676-636


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Description

Description

Suggested positive control: antigen standard for TRIB3 (transient overexpression lysate), human liver lysate, human liver protein.

A novel inhibitor of cell division, Tribbles,  blocks mitosis at a critical point in Drosophila morphogenesis. Recently, mammalian homologues of Tribbles (Trbs) have been identified that control mitogen-activated protein kinase (MAPK) activity.  TRIB3 also known as TRB-3, SINK, and SKIP3 is a member of Trbs family. Overexpression of this protein inhibits NF-kB-dependent transcription induced by tumor necrosis factor (TNF) stimulation or its downstream signaling proteins but does not inhibit NF-kB translocation to the nucleus and binding to DNA. TRIB3/SKIP3 is also overexpressed in multiple human tumors and is regulated by hypoxia.
Specifications

Specifications

TRIB3
Polyclonal
Unconjugated
TRIB3
Liquid
TRIB3
Synthetic peptide corresponding to residues 315-332 of human TRIB3.
Protein G
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Immunofluorescence, Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q96RU7
SKIP3, SINK
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
57761
Documents
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