TRIM25 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520411
A suggested positive control is human thymus tissue lysate. PA5-20411 can be used with blocking peptide PEP-0528.TRIM25, also known as estrogen responsive finger protein (EFP) is a member of the RING finger-B box-coiled coil family and is a downstream target of estrogen receptor a. Mice lacking this gene displayed an underdeveloped uterus and reduced estrogen responsiveness demonstrating that this protein is essential for estrogen dependent proliferation. TRIM25 expression is increased in breast carcinoma where it promotes the growth of breast tumor by functioning as an E3 ubiquitin ligase that targets the negative cell cycle checkpoint 14-3-3s. Recent reports have indicated that TRIM25 E3 ubiquitin ligase is essential for the retinoic-acid-inducible gene 1 (RIG-1) signaling pathway to elicit host antiviral innate immunity.
|A 15 amino acid peptide from near the amino terminus of human TRIM25.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 0.02% sodium azide|
|EFP, RNF147, Z147, ZNF147; E3 ubiquitin/ISG15 ligase TRIM25; RING finger protein 147; estrogen-responsive finger protein; tripartite motif protein TRIM25; tripartite motif-containing 25; tripartite motif-containing protein 25; ubiquitin/ISG15-conjugating enzyme TRIM25; zinc finger protein 147 (estrogen-responsive finger protein); zinc finger protein-147|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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