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TRIM30 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520590

Catalog No. PIPA520590


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Description

Description

A suggested positive control is mouse spleen tissue lysate. PA5-20590 can be used with blocking peptide PEP-0710.

TRIM30 belongs to a family of the tripartite motif (TRIM) proteins involved in the regulation of cell proliferation, differentiation, development, oncogenesis, apoptosis and antiviral responses. The TRIM protein family is an expanding family of RING ( ft.really interesting new gene ft.) proteins, also known as RBCC proteins as they contain an RBCC motif, which comprises a RING domain, one or two B-boxes and a predicted coiled-coil region. Studies have shown that some TRIM family members are critical to innate immunity; TRIM5, TRIM19 and TRIM25, for example, have been shown to restrict viral infection. A recent study shows that TRIM30 functions as a negative modulator of the TLR signaling pathway, by targeting TAB2 and TAB3, and contributes to the inhibition of TLR-mediated NF-kappa-B activation. The importance of TRIM30 in the attenuation or termination of NF-kappa-B activation suggests that targeting of TAB2 and TAB3 by TRIM30-a may be a mechanism for modulating many types of immune responses.
Specifications

Specifications

TRIM30
Polyclonal
Unconjugated
Trim30a
Liquid
TRIM30A
A 16 amino acid peptide near the carboxy terminus of the mouse TRIM30.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P15533
Rpt-1, Rpt1, Trim30; down regulatory protein of interleukin-2 receptor; regulatory protein, T lymphocyte 1; tripartite motif protein 30; tripartite motif-containing 30; tripartite motif-containing protein 30
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
20128
Documents
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