TRIM71 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA521011
A suggested positive control is human brain tissue lysate. PA5-21011 can be used with blocking peptide PEP-1125.TRIM71 is the mammalian ortholog to the C. elegans heterochronic protein Lin41, a protein that is thought to be important in postembryonic development , and is genetically and biochemically downstream of both Shh and Fgf signaling pathways. Similar to its C. elegans homolog, TRIM71 is a target of the microRNA let-7 and is likely to play a role in mammalian development. Recent experiments have indicated that TRIM71 is an E3 ubiquitin ligase and can interact with the Dicer and the Argonaute proteins Ago1, Ago2, and Ago4. Overexpression and depletion of TRIM71 led to inverse changes in Ago2 protein levels, suggesting TRIM71 can regulate Ago2 turnover. Finally, TRIM71 cooperates with the pluripotency factor Lin-28 in regulating let-7.
|A 15 amino acid peptide near the carboxy terminus of human TRIM71.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|Q2Q1W2, Q1PSW8, D3ZVM4|
|LIN-41, LIN41; abnormal cell LINeage LIN-41; homolog of C. elegans Lin-41; protein lin-41 homolog; tripartite motif-containing 71; tripartite motif-containing protein 71|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|131405, 301042, 636931|
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