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TRIM71 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA521011

Catalog No. PIPA521011


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Description

Description

A suggested positive control is human brain tissue lysate. PA5-21011 can be used with blocking peptide PEP-1125.

TRIM71 is the mammalian ortholog to the C. elegans heterochronic protein Lin41, a protein that is thought to be important in postembryonic development , and is genetically and biochemically downstream of both Shh and Fgf signaling pathways. Similar to its C. elegans homolog, TRIM71 is a target of the microRNA let-7 and is likely to play a role in mammalian development. Recent experiments have indicated that TRIM71 is an E3 ubiquitin ligase and can interact with the Dicer and the Argonaute proteins Ago1, Ago2, and Ago4. Overexpression and depletion of TRIM71 led to inverse changes in Ago2 protein levels, suggesting TRIM71 can regulate Ago2 turnover. Finally, TRIM71 cooperates with the pluripotency factor Lin-28 in regulating let-7.
Specifications

Specifications

TRIM71
Polyclonal
Unconjugated
TRIM71
Liquid
TRIM71
A 15 amino acid peptide near the carboxy terminus of human TRIM71.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q2Q1W2, Q1PSW8, D3ZVM4
LIN-41, LIN41; abnormal cell LINeage LIN-41; homolog of C. elegans Lin-41; protein lin-41 homolog; tripartite motif-containing 71; tripartite motif-containing protein 71
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
131405, 301042, 636931
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