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TrkB Sheep anti-Mouse, Rat, Polyclonal, Invitrogen™

Sheep Polyclonal Antibody

Manufacturer:  Invitrogen OST00117W

Catalog No. OST00117W


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Description

Description

Glycerol (1:1) may be added for additional stability. Reconstitute in 100 µl of sterile water.

TrkB is a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). TrkB is involved in the development and maintece of the nervous system. Moreover, Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through TrkB leads to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.
Specifications

Specifications

TrkB
Polyclonal
whole serum with no preservative
P15209, Q63604
Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB/GP95-TrkB, Trk-B, BDNF/NT-3 growth factors receptor
Sheep
IgG
RUO
Antibody
Polyclonal
Mouse, Rat
Immunohistochemistry, Western Blot
Unconjugated
Ntrk2
Lyophilized
NTRK2
A synthetic peptide from the extracellular domain of mouse TrkB
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
18212, 25054
SDS
Documents
Product Certifications
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