TRPM8 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA14282
PA1-4282 detects the Trp-p8 protein in human samples. PA1-4282 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~125 kDa protein representing Trp-p8 in transfected COS cells. PA1-4282 immunizing peptide corresponds to amino acid residues 278-292 and the C terminus sequence of the human Trp-p8 protein.TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH and involved in menthol sensation. TRPM8 is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. TRPM8 has an expression pattern within normal human tissues that is mostly restricted to prostate epithelial cells. TRPM8 mRNA expression is at moderate levels in normal prostate tissue and appears to be elevated in prostate cancer. Notably, TRPM8 mRNA was also expressed in a number of nonprostatic primary tumors of breast, colon, lung, and skin origin, whereas transcripts encoding TRPM8 were hardly detected or not detected in the corresponding normal human tissues.
|Synthetic peptide: R(278) N Q L E K Y I S E R T I Q D(292) and synthetic peptide to the C terminus: (1090) N D L K G L L K E I A N K I K(1104).|
|Antigen affinity chromatography|
|PBS with 0.02% sodium azide|
|Transient receptor potential cation channel subfamily M member 8, Transient receptor potential-p8, Trp-p8 Long transient receptor potential channel 6,|
|-20° C, Avoid Freeze/Thaw Cycles|
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