TRPA1 Rabbit anti-Guinea Pig, Human, Mouse, DyLight® 488, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA522833
The target sequence has 69% sequence homology with rat. Suggested positive control: human brain membrane fraction.TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. TRPA1 is a transformation -associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation. The structure of TRPA1 is highly related to both the protein ankyrin and transmembrane proteins. The specific function of TRPA1 has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control.
|A synthetic peptide made to a region within the N-terminus (residues 1-100) of the human TRPA1 protein.|
|Antigen affinity chromatography|
|Guinea Pig, Human, Mouse|
|Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot|
|sodium borate with 0.05% sodium azide|
|ANKTM1, ankyrin-like with transmembrane domains 1, ankyrin-like with transmembrane domains protein 1, transformation-sensitive protein p120, transient receptor potential cation channel subfamily A member 1|
|4° C, store in dark|
|100526649, 277328, 8989|
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