TRPM2 Rabbit anti-Human, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA522218
PA5-22218 targets TRPM2 in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-22218 immunogen is a recombit fragment corresponding to a region within amino acids 181 and 423 of TRPM2 (Uniprot IDNo.O94759). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.TRPM2 belongs to the ion transport protein family which includes Sodium, Potassium, Calcium ion channels. This family is characterized by proteins possessing 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. TRPM2 is activated by oxidative stress and confers susceptibility to cell death. Further, TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Several alternatively spliced transcript variants of the TRPM2 gene have been described, but their full-length nature is not known.
|Recombit fragment corresponding to a region within amino acids 181 and 423 of TRPM2 (Uniprot IDNo.O94759)|
|Antigen affinity chromatography|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 20% glycerol and 0.025% Proclin 300; pH 7|
|EREG1, KNP3, LTRPC2, NUDT9H, NUDT9L1, TRPC7, LTrpC-2, estrogen-responsive element-associated gene 1 protein, long transient receptor potential channel 2, transient receptor potential cation channel subfamily M member 2, transient receptor potential channel 7|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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