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TRPV1 Rabbit anti-Zebrafish, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen OST00069W

Catalog No. PIOST00069W


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Description

Description

Glycerol (1:1) may be added for additional stability. Reconstitute in 100 µL of sterile water.

TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons. TRPV1 is a non-selective cation channel that is structurally related to members of the TRP family of ion channels such as TRPC3 and TRPC6. TRPV1 is permeable to calcium, magnesium, and monovalent cations of sodium and potassium. Structurally, TRPV1 contains 6 trans-membrane domains, a P-loop membrane domain and 3 ankyrin repeat domains. TRPV1 is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. TRPV1 seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. The expression of TRPV1 appears to be limited to neurons within the sensory ganglia. Four transcript variants encoding TRPV1 with variations in th 5 ft. UTR sequence have been described. Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.
Specifications

Specifications

TRPV1
Polyclonal
whole serum with no preservative
Lyophilized
TRPV1
A synthetic peptide from zebrafish TRPV1, conjugated to an immunogenic carrier protein
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
561195
Immunohistochemistry, Western Blot
Unconjugated
trpv1
Novel protein similar to vertebrate transient receptor potential cation channel, subfamily V, member 1
Rabbit
IgG
RUO
Antibody
Polyclonal
Zebrafish
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