TRPV4 Sheep anti-Human, Polyclonal, Invitrogen™
Sheep Polyclonal Antibody
Supplier: Thermo Scientific OST00034W
Reconstitute with 100 μL of distilled water.TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4) is a cation-selective channel, activated in response to systemic osmotic pressure. Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. TRPV4 is a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The TRPV4 protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in the TRPV4 gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Diseases associated with TRPV4 include Metatropic Dysplasia and Spondylometaphyseal Dysplasia, Kozlowski Type. Multiple transcript variants encoding different isoforms have been found for this gene.
|CMT2C, OTRPC4, TRP12, VR-OAC, VRL-2, VRL2, VROAC
|Immunohistochemistry, Western Blot
|A synthetic peptide from the 1t cytoplasmic loop of human TRPV4
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
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