MilliporeSigma™ anti-TrpV6 Clone: 4A5.1,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABN839

Catalog No. MABN839MI

Description

Specifically detects TrpV6 Clone: 4A5.1 in Human, Mouse, Rat samples, and it is validated for Immunohistochemistry, Western Blotting

Transient receptor potential cation channel subfamily V member 6 (UniProt Q9H1D0; also known as Alu-binding protein with zinc finger domain, Calcium transport protein 1, Calcium transporter-like protein, CaT-L, CaT-like, CaT1, ECaC2, Epithelial apical membrane calcium transporter/channel CaT1, Epithelial calcium channel 2, TrpV6) is encoded by the TRPV6 (also known as ABP/ZF, CAT1, CATL, ECAC2, ZFAB) gene (Gene ID 55503) in human. TRPV6 belongs to the transient receptor potential (TRP) family of membrane proteins. The human TRPV6 is an 765-amino acid, six-transmembrane protein with both N- and C-termini exposed intracellularly. TRPV6 contains a pore-forming loop domain located between the fifth and sixth transmembrane region. Among all the TRPV family members, TRPV5 and TRPV6 are the two highly Ca2+-selective channels that play pivotal roles in the Ca2+-reabsorption in the kidney and intestine, respectively. TRPV6 is found in the apical brush-border membrane of the intestinal enterocytes where it regulates calcium entry into the cells. TRPV6 expression is also reported in human placenta, pancreas, and prostate gland. Vitamin D treatment of human colon cancer Caco-2 cells and duodenal explants results in upregulated TRPV6 mRNA levels.

Specifications

• Antigen: TrpV6
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene Accession No.: Q9H1D0
• Host Species: Mouse
• Purification Method: Unpurified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Expected to react with both spliced isoforms of human TrpV6 reported by UniProt (Q9H1D0).
• Content And Storage: -20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
• Isotype: IgG2a κ

• Applications: Immunohistochemistry, Western Blot
• Clone: 4A5.1
• Formulation: In culture supernatant without preservatives.
• Gene Symbols: TRPV6, ABP/ZF, CAT1, CATL, ECAC2, ZFAB
• Immunogen: GST-tagged recombinant human TrpV6 C-terminal fragment.
• Quantity: 100 μL
• Research Discipline: Neuroscience
• Gene ID (Entrez): NP_061116
• Target Species: Human, Mouse, Rat
• Form: Supernatant

For Research Use Only