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TRPV6 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen OSR00128W

Catalog No. PIOSR00128W


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Description

Description

Glycerol (1:1) may be added for additional stability. Reconstitute in 100 µL of sterile water.

Calcium-permeable channels, such as TRPV6, participate in neurotransmission, muscle contraction, and exocytosis by providing calcium as an intracellular second messenger. Depending on the tissue, transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH), or calcitonin (CALCA). Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. Interacts with TRPV5. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with BSPRY. Interacts with calmodulin.
Specifications

Specifications

TRPV6
Polyclonal
whole serum with no preservative
Q9H1D0
TrpV6, epithelial calcium channel 2, ECaC2, calcium transport protein 1, CaT1, CaT-like, CaT-L
Rabbit
IgG
RUO
Antibody
Polyclonal
Human
Immunohistochemistry, Western Blot
Unconjugated
TRPV6
Lyophilized
TRPV6
A synthetic peptide from the 1t extracellular loop of human TRPV6 conjugated to an immunogenic carrier protein
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
55503
Documents
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