TrxR1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527861
PA5-27861 targets TrxR1 in IHC (P) and WB applications and shows reactivity with Human, mouse, and Rat samples. The PA5-27861 immunogen is recombit fragment corresponding to a region within amino acids 299 and 617 of Human TrxR1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3 ft. UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.
|Recombit fragment corresponding to a region within amino acids 299 and 617 of Human TrxR1|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7|
|Q16881, Q9JMH6, O89049|
|GRIM-12, TR, TR1, TRXR1, TXNR, KM-102-derived reductase-like factor, gene associated with retinoic and IFN-induced mortality 12 protein, gene associated with retinoic and interferon-induced mortality 12 protein, oxidoreductase, thioredoxin reductase 1, cytoplasmic, thioredoxin reductase GRI|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|50493, 58819, 7296|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok