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TSLP Rat anti-Mouse, Clone: 152640, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA523779

Catalog No. PIMA523779



Description

Description

In Western blots, this antibody does not cross-react with recombit mouse IL-7 or recombit human TSLP. Reconstitute at 0.5 mg/mL in sterile PBS.

TSLP is a 159 amino acid four helix-bundle hemopoietic cytokine that signals through a heterodimeric receptor complex consisting of the human TSLP receptor and the IL-7R alpha-chain. It impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes, enhances the maturation of CD11c (+) dendritic cells, naive CD4 (+), and CD8 (+) T cells into proallergic effectors, and primes dendritic cells to produce large amounts of IL-12 after CD40 ligand stimulation. TSLP influences the regulation of the positive selection of regulatory T cells and maintece of peripheral CD4 (+) T cell homeostasis. It induces allergic inflammation by directly activating mast cells and may be involved in the pathophysiology of inflammatory arthritis. It is expressed in heart, liver and prostate.
Specifications

Specifications

TSLP
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q9JIE6
thymic stroma-derived lymphopoietin
Rat
IgG2a
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
53603
ELISA, Western Blot
152640
Unconjugated
Tslp
Lyophilized
TSLP
Sf 21-derived recombit mouse TSLP Tyr20-Glu140
Protein A/G
RUO
Antibody
Monoclonal
Mouse
Documents
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