TSLP Rat anti-Mouse, Clone: 152640, Invitrogen
Rat Monoclonal Antibody
Manufacturer: Invitrogen MA523875
In Western blots, this antibody does not cross-react with recombit mouse IL-7 or recombit human TSLP. Reconstitute at 0.5 mg/mL in sterile PBS.TSLP is a 159 amino acid four helix-bundle hemopoietic cytokine that signals through a heterodimeric receptor complex consisting of the human TSLP receptor and the IL-7R alpha-chain. It impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes, enhances the maturation of CD11c (+) dendritic cells, naive CD4 (+), and CD8 (+) T cells into proallergic effectors, and primes dendritic cells to produce large amounts of IL-12 after CD40 ligand stimulation. TSLP influences the regulation of the positive selection of regulatory T cells and maintece of peripheral CD4 (+) T cell homeostasis. It induces allergic inflammation by directly activating mast cells and may be involved in the pathophysiology of inflammatory arthritis. It is expressed in heart, liver and prostate.
|PBS with 5% trehalose and No Preservative|
|thymic stroma-derived lymphopoietin|
|-20° C, Avoid Freeze/Thaw Cycles|
|ELISA, Western Blot|
|Sf 21-derived recombit mouse TSLP Tyr20-Glu140|
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