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TEM7 Mouse anti-Human, Mouse, Rat, Clone: 197C193 (IM193), Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA141065

Catalog No. 01-676-458


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Description

Description

Suggested positive control: antigen standard for PLXDC1 (transient overexpression lysate), HCT-116.

Recently, using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). TEM7 (Tumor endothelial marker 7) transcripts are specifically expressed in the endothelium of colorectal cancer, primary cancers of lung, pancreas, breast, and brain. TEM7 is expressed specifically in endothelium of these cancers, whether primary or metastasis. The other six members of this family (TEM1, 3, 4, 5, 8, and 9) also show similar expression pattern in lung and brain tumors, and liver metastasis. Since most of the genes expressed differentially in tumor endothelium are also expressed during angiogenesis, these newly discovered genes might provide important resources for basic and clinical studies of human angiogenesis.
Specifications

Specifications

TEM7
Monoclonal
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q8IUK5, Q91ZV7
TEM7
Mouse
IgG1
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
303505, 57125, 72324
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
197C193 (IM193)
Unconjugated
PLXDC1
Liquid
PLXDC1
Synthetic petide corresponding to residues 409-425 of human TEM7.
Protein G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
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