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TWEAK Mouse anti-Human, Clone: 173830, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523783

Catalog No. PIMA523783


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Description

Description

In sandwich ELISAs, approximately 15% reactivity with recombit mouse TWEAK is observed and no cross-reactivity with recombit human (rh) BAFF, rhEDA-A2, rhLIGHT, rhFas Ligand, rhGITR Ligand, rhLT alpha 1 beta 2, rhLT alpha 2 beta 1, rhOX40 Ligand, rhTNF-alpha, rhTRANCE, rhTRAIL, rh4-1BB, or rhAPRIL is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane. TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis, induction of inflammatory cytokines, in addition to stimulation of apoptosis. The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains.
Specifications

Specifications

TWEAK
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
O43508
UNQ181/PRO207, APO3L, DR3LG, TWEAK, APO3 ligand, APO3/DR3 ligand, TNF-related WEAK inducer of apoptosis, tumor necrosis factor ligand superfamily member 12
Mouse
IgG1
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
8742
ELISA
173830
Unconjugated
TNFSF12
Lyophilized
TNFSF12
E. coli-derived recombit human TWEAK/TNFSF12 Arg93-His249
Protein A/G
RUO
Antibody
Monoclonal
Human
Documents
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