Tyrosine Hydroxylase Sheep anti-Many, Polyclonal, Invitrogen
Sheep Polyclonal Antibody
Manufacturer: Invitrogen PA14679
This antibody is specific for the ~60 kDa Tyrosine Hydroxylase in Western blots of rat brain extracts.Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson ft.s disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.
|0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5|
|P17289, Q76IQ3, P07101, P24529, P04177|
|TH, TYH, Tyrosine 3 monooxygenase|
|-20° C, Avoid Freeze/Thaw Cycles|
|21823, 25085, 280707, 403444, 7054|
|Dot blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|SDS-denatured, native rat tyrosine hydroxylase purified from pheochromocytoma|
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