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Tyrosine Hydroxylase Sheep anti-Many, Polyclonal, Invitrogen™

Sheep Polyclonal Antibody

Manufacturer:  Invitrogen PA14679

Catalog No. PA14679

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This antibody is specific for the ~60 kDa Tyrosine Hydroxylase in Western blots of rat brain extracts.

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson ft.s disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.


Tyrosine Hydroxylase
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
P17289, Q76IQ3, P07101, P24529, P04177
TH, TYH, Tyrosine 3 monooxygenase
100 μL
-20° C, Avoid Freeze/Thaw Cycles
21823, 25085, 280707, 403444, 7054
Dot blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
SDS-denatured, native rat tyrosine hydroxylase purified from pheochromocytoma
Affinity chromatography
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