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Tyrosine Hydroxylase Rabbit anti-Guinea Pig, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA118315

Catalog No. 01-670-568


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Description

Description

PA1-18315 detects Tyrosine Hydroxylase from rat, mouse, and guinea pig samples. PA1-18315 has been successfully used in immunohistochemistry (frozen sections) and immunohistochemistry (paraffin-embedded sections) procedures. The PA1-18315 immunogen is a synthetic peptide corresponding to residues P (63) R F I G R R Q S L I E D A R K(78) of human Tyrosine Hydroxylase conjugated to KLH. Reconstitute with 100 µL of distilled water.

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson ft.s disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.
Specifications

Specifications

Tyrosine Hydroxylase
Polyclonal
whole serum with no preservative
P24529, P04177
TH, Tyrosine 3-monooxygenase, L-tyrosine hydroxylase, Tyrosine 3-hydroxylase
Rabbit
IgG
RUO
Antibody
Polyclonal
Guinea Pig, Mouse, Rat
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Unconjugated
Th
Lyophilized
TH
Synthetic peptide corresponding to residues P (63) R F I G R R Q S L I E D A R K(78) of human Tyrosine Hydroxylase conjugated to KLH.
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
100734150, 21823, 25085
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