TrkA Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA118405
PA1-18405 detects Tyrosine Kinase Receptor A from human, mouse, and rat samples. PA1-18405 has been successfully used in immunohistochemistry and ELISA procedures. The PA1-18405 immunogen is the extracellular domain of glycosylated human TrkA protein produced in CHO. Reconstitute with 100 µL of distilled water.TrkA (tropomyosin receptor kinase A) encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of TrkA leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. Mutations in the TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.
|whole serum with no preservative|
|P04629, Q3UFB7, P35739|
|Human, Mouse, Rat|
|Extracellular domain of glycosylated human TrkA protein produced in CHO cells.|
|-20° C, Avoid Freeze/Thaw Cycles|
|18211, 4914, 59109|
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