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TYW1 Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA521152

Catalog No. PIPA521152


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Description

Description

A suggested positive control is human lung tissue lysate. PA5-21152 can be used with blocking peptide PEP-1266.

TYW1, also known as TYW1A, RSAFD1 or YPL207W, is a 732 amino acid protein containing one flavodoxin-like domain that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW1 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW1 binds to one 4Fe-4S cluster and is located on human chromosome 7. Defects in some of the genes on chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome, suggesting that TYW1 may play a role in these conditions
Specifications

Specifications

TYW1
Polyclonal
Unconjugated
TYW1
Liquid
TYW1
A 19 amino acid peptide near the carboxy terminus of human TYW1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Rat
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9NV66
RSAFD1, TYW1A, YPL207W; radical S-adenosyl methionine and flavodoxin domain-containing protein 1; radical S-adenosyl methionine and flavodoxin domains 1; tRNA wybutosine-synthesizing protein 1 homolog; tRNA-yW synthesizing protein 1 homolog A; tRNA-yW-synthesizing protein
Rabbit
IgG
100 μg
4° C
Primary
304423, 55253
Documents
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