UbcH6 Mouse, Unlabeled, Clone: 42, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611218
Maintenance of cellular function requires timely and selective degradation of key regulatory proteins. For example, progression of the mammalian cell cycle is regulated by phosphorylation/dephosphorylation and synthesis/degradation of many key proteins via the ubiquitin pathway. Ubiquitin, a soluble protein of 76 amino acids, is enzymatically attached to an ε-NH2-Lys in a target protein. Ubiquitin-conjugated proteins are recognized and degraded by the 26S proteasome. Ubiquitination requires ubiquitin-activating enzyme E1, ubiquitin conjugating enzymes E2, and ubiquitin ligases E3. The direction of ubiquitin transfer is from E1 to E2 and from E2 to E3. E6-AP is a human E3 which, in complex with the E6 protein of human papillomaviruses, induces the ubiquitination and degradation of p53. UbcH6 is a human homolog of the S. cerevisiae ubiquitin-conjugating enzyme (Ubc), UBC4, which interacts with E6-AP. UbcH6 also interacts with E6-AP. However, it has little effect on E6-AP-dependent ubiquitination. The precise physiological function of UbcH6 remains to be determined.
Host Species: Mouse
Species Reactivity: Human
Immunogen: Human UbcH6 aa. 46-58
Formula Weight [Chemical]: 21kDa
Immunofluorescence, Western Blotting
|Canine, Human, Murine, Rat|
|Immunofluorescence, Western Blot|
|Human UbcH6 aa. 46-58|
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