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UBE1L Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527997

Catalog No. PIPA527997


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Description

Description

PA5-27997 targets UBE1L in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-27997 immunogen is recombit fragment corresponding to a region within amino acids 1 and 297 of Human UBE1L. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein.
Specifications

Specifications

UBE1L
Polyclonal
Unconjugated
UBA7
Liquid
UBA7
Recombit fragment corresponding to a region within amino acids 1 and 297 of Human UBE1L
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
P41226
D8, UBA1B, UBE1L, UBE2, UBA1, ubiquitin-activating enzyme E1 homolog B, UBA7, ubiquitin-activating enzyme E1, ubiquitin-activating enzyme 7, ubiquitin-activating enzyme E1 homolog, ubiquitin-activating enzyme E1-related protein, ubiquitin-activating enzyme-2, ubiquitin-like modifier-a
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
7318
Documents
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