UBE2V1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA512044

Catalog No. PIPA512044

Description

This antibody is predicted to react with bovine, chicken, rat and Xenopus and zebrafish based on sequence homology.

Ubiquitin-conjugating enzyme E2 (UEV1) was initially discovered as a protein similar in sequence and structure to the E2 ubiquitin-conjugating enzymes but lacking their enzymatic activity. There are at least two variants and multiple isoforms of UEV1. In particular, UEV1A (Ubiquitin-conjugating enzyme E2 variant 1 isoform A) has recently been shown to be an important component of the Toll-like receptor and IL-1R signaling pathway. Signals from these pathways are relayed by a number of downstream molecules such as MyD88 and tumor necrosis factor receptor associated factor (TRAF6), ultimately activating various kinases and transcription factors. UEV1A is part of a dimeric ubiquitin-conjugating enzyme complex also containing Ubc13 (ubiquitin-conjugating enzyme 13) that together with TRAF6 activates TAK1, a member of the mitogen-activated protein kinase kinase kinase family. The Ubc13-UEV1A complex also mediates the Lys-63 ubiquitination of TRAF-6, and this ubiquitination is essential for TAK1 activation.

Specifications

• Antigen: UBE2V1
• Classification: Polyclonal
• Gene: UBE2V1
• Gene Alias: DJ1185N5.1.3; Ubiquitin-conjugating enzyme E2 variant 1 (Isoform 3, CROC-1A); TRAF6-regulated IKK activator 1 beta Uev1A; Ubiquitin-protein ligase; Ubiquitin carrier protein
• Host Species: Rabbit
• Purification Method: Ammonium sulfate precipitation, Size-exclusion - Dialysis
• Regulatory Status: RUO
• Gene ID (Entrez): 66589, 7335
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Conjugate: Unconjugated
• Gene Accession No.: Q13404, Q9CZY3
• Gene Symbols: UBE2V1
• Immunogen: KLH conjugated synthetic peptide between 113-145 amino acids from the C-terminal region of human UBE2V1
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG