PGP9.5 Mouse anti-Rat, Clone: BH7, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen 480012
DescriptionPGP9.5 (Protein gene product 9.5, UCH-L1, PARK5) is a neuron specific protein, structurally and immunologically distinct from neuron specific enolase. PGP9.5 has a molecular weight of 27 kDa and was first identified by high resolution two dimensional PAGE. PGP9.5 is a member of ubiquitin carboxyl-terminal hydrolase family 1 (peptidase family C12) with a ubiquitin carboxyl-terminal hydrolase domain. PGP9.5 is well known for having ubiquitin hydrolase and ligase activities that hydrolyzes small C-terminal adducts of ubiquitin to generate ubiquitin monomers. PGP9.5 is present in neurons and nerve fibers at all levels of the central and peripheral nervous system, in neuroendocrine cells, in segments of the renal tubules, in spermatogonia and Leydig cells of the testis, in ova and in some cells of both the pregt and non-pregt corpus luteum. Over expression of PGP9.5 leads to non-small cell lung cancer while decreased expression leads to Huntington disease and Alzheimer disease. Since PGP9.5 is present in cellular inclusions, it can be a useful as a neuronal marker and in the studies of neurodegenerative disorders such as with Parkinson disease.
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|Recombit full length human UCHL1 purified from E. coli.|
|Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|tissue culture supernatant with 10mM sodium azide|
|neuron cytoplasmic protein 9.5, ubiquitin C-terminal hydrolase, ubiquitin carboxyl-terminal hydrolase isozyme L1, ubiquitin thioesterase L1|
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