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PGP9.5 Chicken anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Chicken Polyclonal Antibody

Manufacturer:  Invitrogen PA146204

Catalog No. PA146204


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Description

Description

Suggested positive control: antigen standard for UCHL1 (transient overexpression lysate), rat spinal cord or perpheral nerve homogenate.

PGP9.5 (Protein gene product 9.5, UCH-L1, PARK5) is a neuron specific protein, structurally and immunologically distinct from neuron specific enolase. PGP9.5 has a molecular weight of 27 kDa and was first identified by high resolution two dimensional PAGE. PGP9.5 is a member of ubiquitin carboxyl-terminal hydrolase family 1 (peptidase family C12) with a ubiquitin carboxyl-terminal hydrolase domain. PGP9.5 is well known for having ubiquitin hydrolase and ligase activities that hydrolyzes small C-terminal adducts of ubiquitin to generate ubiquitin monomers. PGP9.5 is present in neurons and nerve fibers at all levels of the central and peripheral nervous system, in neuroendocrine cells, in segments of the renal tubules, in spermatogonia and Leydig cells of the testis, in ova and in some cells of both the pregt and non-pregt corpus luteum. Over expression of PGP9.5 leads to non-small cell lung cancer while decreased expression leads to Huntington disease and Alzheimer disease. Since PGP9.5 is present in cellular inclusions, it can be a useful as a neuronal marker and in the studies of neurodegenerative disorders such as with Parkinson disease.
Specifications

Specifications

PGP9.5
Polyclonal
PBS with 5mM sodium azide
Q00981, P09936, Q9R0P9
PARK5, PGP9.5, PGP95, Uch-L1
Chicken
IgY
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
29545, 7345, 22223
Immunocytochemistry, Immunofluorescence, Western Blot
Unconjugated
UCHL1
Liquid
UCHL1
Recombit full length human UCHL1 purified from E. coli.
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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