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ULK2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA515382

Catalog No. PIPA515382


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Description

Description

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). Two human homologs of the yeast autophagy-specific kinase exist: ULK1(APG1) and ULK2. APG1 plays a critical role in regulating key elements of the autophagy pathway. APG1 stimulates autophagy, leading to autophagy-dependent restriction of cell growth and ultimately cell apoptosis at high levels of activity, and is a negative regulator of mTOR signaling.
Specifications

Specifications

ULK2
Polyclonal
PBS with 0.09% sodium azide
Q8IYT8, Q9QY01
Serine/threonine-protein kinase ULK2; unc-51-like kinase 2; KIAA0623
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
29869, 9706
Western Blot
Unconjugated
ULK2
Liquid
ULK2
KLH conjugated synthetic peptide between 612-643 amino acids from the C-terminal region of human ULK2
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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