ULK2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA522173
PA5-22173 targets ULK2 in ICC, IF, IHC (P), and WB applications and shows reactivity with Human and Mouse samples. The PA5-22173 immunogen is a recombit fragment corresponding to a region within amino acids 693 and 968 of ULK2 (Uniprot IDNo.Q8IYT8). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.ULK2, also known as ATG1B, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK2 results in a severe defect in the autophagy pathway. ULK2 is highly conserved among eukaryotes and shows high homology with its related protein ULK1. Both ULK1 and ULK2 form a complex with ATG13 and FIP200 that mediates TOR signaling and is essential for autophagy. Like ULK1, ULK2 is also thought to be involved in early neuronal growth and differentiation.
|Recombit fragment corresponding to a region within amino acids 693 and 968 of ULK2 (Uniprot IDNo.Q8IYT8)|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 20% glycerol and 0.025% ProClin 300; pH 7|
|ATG1B, Unc51.2, serine/threonine-protein kinase ULK2|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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