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ULK2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA522173

Catalog No. PIPA522173


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Description

Description

PA5-22173 targets ULK2 in ICC, IF, IHC (P), and WB applications and shows reactivity with Human and Mouse samples. The PA5-22173 immunogen is a recombit fragment corresponding to a region within amino acids 693 and 968 of ULK2 (Uniprot IDNo.Q8IYT8). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

ULK2, also known as ATG1B, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK2 results in a severe defect in the autophagy pathway. ULK2 is highly conserved among eukaryotes and shows high homology with its related protein ULK1. Both ULK1 and ULK2 form a complex with ATG13 and FIP200 that mediates TOR signaling and is essential for autophagy. Like ULK1, ULK2 is also thought to be involved in early neuronal growth and differentiation.
Specifications

Specifications

ULK2
Polyclonal
Unconjugated
ULK2
Liquid
ULK2
Recombit fragment corresponding to a region within amino acids 693 and 968 of ULK2 (Uniprot IDNo.Q8IYT8)
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Q8IYT8, Q9QY01
ATG1B, Unc51.2, serine/threonine-protein kinase ULK2
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
29869, 9706
Documents
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