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UNC93B1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520510

Catalog No. PIPA520510


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Description

Description

A suggested positive control is human heart tissue lysate. PA5-20510 can be used with blocking peptide PEP-0630.

The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9; the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity.
Specifications

Specifications

UNC93B1
Polyclonal
Unconjugated
UNC93B1
Liquid
UNC93B1
A 19 amino acid peptide from near the amino terminus of human Unc93b.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9H1C4, Q8VCW4
UNC93, UNC93B, Unc-93B1; hUNC93B1; protein unc-93 homolog B1; unc-93 related protein; unc93 homolog B; unc93 homolog B1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
361689, 54445, 81622
Documents
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