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UNG Rabbit anti-Human, Mouse, Rabbit, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141024

Catalog No. 01-676-638



Description

Description

This sequence also corresponds to residues 290-307 of human UNG2. Suggested positive control: antigen standard for UNG (transient overexpression lysate), Hela whole cell extract.

The human UNG gene encodes both nuclear (UNG2) and mitochondrial (UNG1) forms of uracil-DNA glycosylase.  These forms are generated by alternative splicing and the use of two differentially regulated promoters, PA and PB (Slupphaug et al., 1993; Nilsen et al., 1997)  The cDNAs for UNG1 and UNG2 are of similar size (2061 and 2058 bp, respectively) and as a result the corresponding mRNAs are not resolved as two species in gel electrophoresis (Huag et al., 1998). Nuclear UNG2 differs from mitochondrial UNG1 in 44 amino acids of the N-terminal sequence that is not necessary for catalytic activity. A major role of the UNG gene products is to repair mutagenic U:G mispairs caused by cytosine deamination. For example, UNG2 removes misincorporated dUMP residues.   The level and expression pattern of UNG1 and UNG2 differs between cell and tissue type (Huag et al. 1998).  Additionally, the expression of UNG is cell cycle regulated  (Nagelhus et al. 1995).   The expression and activity of UNG has been found in general to be higher in proliferating as compared to nonproliferating tissues and cells (reviewed in Kruman et al. 2004).  UNG1 is a 304 amino acid protein. UNG2 is a 313 amino acid protein.
Specifications

Specifications

UNG
Polyclonal
Unconjugated
UNG
Liquid
UNG
Synthetic peptide corresponding to residues C(281) R H F S K T N E L L Q K S G K K P(298) of human UNG1 (NP 003353.1).
Protein G
RUO
Antibody
Polyclonal
Human, Mouse, Rabbit, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
P13051, P97931
DGU, DKFZp781L1143, HIGM4, UDG, UNG1, UNG15, UNG2
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100338366, 22256, 304577, 7374
Documents
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