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uPAR Mouse anti-Human, Clone: R-4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MONR402

Catalog No. PIMONR402


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Description

Description

Specificity: MON R-4-02 does not cross-react with mouse uPAR, human uPA, human tPA or human PAI-1 when tested by ELISA and immunoblotting. Reactivity: MON R-4-02 reacts with domain 3 in immunoprecipitation using proteolytic fragments of recombit suPAR. This antibody is suitable for Western blotting of non-reduced proteins and can be used as a detection antibody in ELISA applications. NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL

Urokinase plasminogen activator receptor (uPAR), also known as CD87, is a glycolipid anchored cell surface protein consisting of three homologous domains. It binds uPA with high affinity and enhances and localizes uPA catalyzed plasminogen activation, and thereby plays a key role in cancer invasion and in several tissue remodelling processes. In addition uPAR also binds to vitronectin and may thereby have biological functions independent of its role in uPA mediated proteolysis. Elevated levels of uPAR are associated with poor prognosis in many types of cancer.
Specifications

Specifications

uPAR
Monoclonal
1.11 mg/mL
PBS with 15mM sodium azide; pH 7.4
Q03405
CD87, UPAR, URKR, PLAUR, MO3
Mouse
IgG1
200 μL
4° C, store in dark
Primary
5329
ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
R-4
Unconjugated
PLAUR
Liquid
PLAUR
Native human uPAR.
Protein A
RUO
Antibody
Monoclonal
Human
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